Several MLPA probemixes contain one or more so-called mutation specific probes. These probes are targeted to known mutations and only give a signal when the mutation for which the probe is designed is present. As the mutations targeted by these probes are normally not present in the genome of healthy individuals, the analysis and the display of the results of mutation specific probes in Coffalyser.Net slightly differ from regular MLPA probes.
For more information on the analysis and display of mutation specific probes please see Appendix I on pages 34-37 of the Coffalyser.Net Reference Manual.
The information provided in this material is correct for the majority of our products. However, for certain applications, the instructions for use may differ. In the event of conflicting information, the relevant instructions for use take precedence.