Flyer: digitalMLPA NXtec D007 Acute Lymphoblastic Leukemia

NXtec D007 Acute Lymphoblastic Leukemia is a new generation panel detecting an extensive number of ALL-associated genes and regions, as well as gross copy number alterations (CNAs). Bring down lab-handling time and optimise your resources with its targeted approach.

Recurrent and clonal genetic alterations in different subtypes of Acute Lymphoblastic Leukemia (ALL) are well-characterised, and associated with differences in disease outcome. MRC Holland’s SALSA^® MLPA^® technology has become a prime method in studying CNAs in ALL, especially IKZF1^del. This assay is based on the groundbreaking digitalMLPA technology, which combines the broad scale of next generation sequencing with the unparalleled sensitivity in CNA detection of MLPA. In a single reaction, NXtec D007 Acute Lymphoblastic Leukemia can detect:

• Partial chromosome gains, losses and high-level amplifications.

• Hyperdiploidy and hypodiploidy.

• Intrachromosomal gene fusions.

• Intragenic CNAs.