Flyer: digitalMLPA NXtec D007 Acute Lymphoblastic Leukemia

NXtec D007 Acute Lymphoblastic Leukemia is a new generation panel detecting an extensive number of ALL-associated genes and regions, as well as gross copy number alterations (CNAs). Bring down lab-handling time and optimise your resources with its targeted approach.

Recurrent and clonal genetic alterations in different subtypes of acute lymphoblastic leukemia (ALL) are well characterised and are associated with differences in disease outcome. MRC Holland’s SALSA MLPA technology has already become a leading method for studying CNAs in ALL, especially IKZF1 deletions (IKZF1^del).

To extend these capabilities, the NXtec D007 Acute Lymphoblastic Leukemia assay is based on digitalMLPA technology, which combines the broad scale of next-generation sequencing with high sensitivity for copy number detection. In ALL, the assay provides high resolution copy number detection beyond the scope of complementary techniques, such as RNA sequencing or FISH. In a single reaction, the assay can identify:

• Partial chromosome gains, losses and high-level amplifications
• Hyperdiploidy (detection); hypodiploidy (confirmation)
• Intrachromosomal gene fusions
• Intragenic CNAs