Methylation-Specific (MS)-MLPA® is a variant of the MLPA technique, the gold standard in copy number determination. Combining MLPA with the methylation-sensitive endonuclease HhaI allows for the detection of both DNA copy number and methylation status. With MS-MLPA, simultaneous semi-quantitative methylation profiling of multiple targets is accomplished easily and without bisulfite treatment.
This flyer provides an overview of the MS-MLPA technique and some of the most popular applications. More information about our products can be found in one of our application-specific brochures, via our assay finder, or in our full product catalogue. More information about MLPA in general can be found in this brochure.