Methylation-Specific (MS)-MLPA^® is a variant of the MLPA technique, the gold standard in copy number determination. By combining the MLPA technique with the use of the methylation-sensitive endonuclease HhaI, it is possible to detect both DNA copy number and methylation status without bisulfite treatment. With MS-MLPA, semiquantitative methylation profiling of multiple targets is accomplished simultaneously and with ease.

This brochure provides an overview of the MS-MLPA technique and some of their most popular applications. More information about our products can be found in one of our application-specific brochures, via our assay finder, or in our full product catalogue. More information about MLPA in general can be found in this brochure.